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Gliclazide, a second-generation sulfonylurea, lowers blood glucose by stimulating insulin release from pancreatic β-cells. This occurs by enhancing calcium ion influx across the β-cell membrane. Additionally, it reduces hepatic glucose production, contributing to improved glycemic control. Hypoglycemia or hyperglycemia may impair concentration and reaction time. Caution is advised when driving or operating machinery.
- Not recommended for pediatric use.
- Not recommended during pregnancy.
- Contraindicated while breastfeeding.
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✅ Description:
Diamicron MR is an oral antidiabetic medication from the sulfonylurea class, indicated for the treatment of Type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and weight control alone are insufficient to maintain optimal blood sugar levels.
Overdose: May cause severe hypoglycemia. Take sugar or sweet fluids immediately and seek emergency medical help.
Missed dose: Skip and resume regular dosing. Do not double up.
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✔️ Side Effects
Common: Hypoglycemia (shakiness, sweating, confusion)
Digestive issues: Nausea, diarrhea, constipation
Skin reactions: Rash, itching, urticaria, angioedema
Hepatic effects: Rare liver dysfunction or jaundice
Hematologic effects: Rare blood cell abnormalities
Visual disturbances: Temporary changes in vision at therapy start
✔️ Dosage & Administration
▸ Immediate-Release (IR) Tablet:
Starting dose: 40–80 mg/day, taken before meals.
Maximum dose: 320 mg/day in divided doses.
Not recommended for children (juvenile diabetes).
▸ Modified-Release (MR) Tablet:
Usual dose: 1–4 tablets daily (up to 120 mg) taken once daily with breakfast.
Swallow whole with water. Do not crush or chew.
Always follow the doctor’s dosing instructions, especially if combining with other antidiabetic agents (e.g., metformin, insulin).
✔️ Do not use Gliclazide if you:
- Have Type 1 diabetes, diabetic ketoacidosis, or are in a diabetic coma.
- Suffer from severe liver or kidney dysfunction.
- Are allergic to sulfonylureas or sulfonamides.
- Are currently breastfeeding or using miconazole (antifungal).
✔️ Interactions
⚠ May increase risk of hypoglycemia when taken with:
Other antidiabetics (e.g., insulin, GLP-1 agonists)
Certain antibiotics (e.g., sulphonamides, clarithromycin)
Antifungals (e.g., miconazole, fluconazole)
ACE inhibitors, beta-blockers
NSAIDs, alcohol
⚠ May reduce efficacy with:
Corticosteroids, danazol
Certain CNS drugs (e.g., chlorpromazine)
Fluoroquinolone antibiotics can cause glycemic disturbances.
✔️ Precautions & Warnings
Monitor blood glucose regularly.
Increased risk of hypoglycemia if:
- Skipping meals
- Fasting
- Malnourished
- Excessive exercise without adjusting food intake
- Taking alcohol or interacting with medications
- May require insulin during surgery, infection, or other stress.
- Use with caution in patients with G6PD deficiency due to the risk of hemolytic anemia.
✔️ Storage
Store below 30°C.
Keep out of reach of children.
Do not use beyond the expiry date.
Dispose of unused medication responsibly.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
